Skip to main content
SpringerLink
Log in

Glypicans (GPCs)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 142 Accesses

Synonyms

Glypican-1: Glypican; Glypican 1; Glypican-1; GPC1

Glypican-2: Glypican 2; Glypican-2; GPC2; Cerebroglycan

Glypican-3: Glypican 3; Glypican-3; GPC3; MXR7; OCI-5

Glypican-4: Glypican 4; Glypican-4; GPC4; K-glypican

Glypican-5: Glypican 5; Glypican-5; GPC5

Glypican-6: Glypican 6; Glypican-6; GPC6

Historical Background

Glypican-3 (GPC3) is the first glypican that was cloned (Filmus et al. 1988). Initially named OCI-5, GPC3 was identified in 1988 as a gene whose expression was developmentally regulated in the intestine. Two years later, the cloning of Glypican-1 (GPC1) was reported. This report characterized GPC1 as a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan (HSPG), but it did not indicate that GPC1 displays significantly homology with GPC3 (David et al. 1990). This homology was noticed 4 years later in a study that reported the cloning of Glypican-2 (initially called cerebroglycan) (Stipp et al. 1994). This study established for the first time the...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Allen NJ, Bennett ML, Foo LC, Wang GX, Chakraborty C, Smith SJ, et al. Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature. 2012;486:410–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53:1020–2.

    Article  PubMed  Google Scholar 

  • Campos-Xavier AB, Martinet D, Bateman J, Belluocio D, Rowley L, Tan TY, et al. Mutations in the heparan-sulfate proteoglycan glypican-6 (GPC6) impair endochodral ossification and cause recessive omodysplasia. Am J Hum Genet. 2009;84:760–70.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Capurro MI, Xu P, Shi W, Li F, Jia A, Filmus J. Glypican-3 inhibits hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell. 2008;14:700–11.

    Article  PubMed  CAS  Google Scholar 

  • David G, Lories V, Decock B, Marynen P, Cassiman J, Van Den Berghe H. Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts. J Cell Biol. 1990;111:3165–76.

    Article  PubMed  CAS  Google Scholar 

  • Filmus J, Capurro M. Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma. FEBS J. 2013;280:2471–6.

    Article  PubMed  CAS  Google Scholar 

  • Filmus J, Capurro M. The role of glypicans in Hedgehog signaling. Matrix Biol. 2014;35:248–52.

    Article  PubMed  CAS  Google Scholar 

  • Filmus J, Church JG, Buick RN. Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine. Mol Cell Biol. 1988;8:4243–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Filmus J, Capurro M, Rast J. Glypicans. Genome Biol. 2008;9:224.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gao W, Tang Z, Zhang YF, Feng M, Qian M, Dimitrov DS, et al. Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis. Nat Commun. 2015;6:6536.

    Article  PubMed  CAS  Google Scholar 

  • Jackson SM, Nakato H, Sugiura M, Jannuzi A, Oakes R, Kaluza V, et al. dally, a Drosophila glypican, controls celular responses to the TGF-beta-related morphogen Dpp. Development. 1997;124:4113–20.

    PubMed  CAS  Google Scholar 

  • Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, et al. PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci USA. 2015;112:1874–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li F, Shi W, Capurro M, Filmus J. Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling. J Cell Biol. 2011;192:691–704.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lin X, Perrimon N. Dally cooperates with Drosophila Frizzled 2 to transduce wingless signaling. Nature. 1999;400:281–4.

    Article  PubMed  CAS  Google Scholar 

  • Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, et al. Identification of hedgehog pathway components by RNAi in Drosophila cultured cells. Science. 2003;299:2039–45.

    Article  PubMed  CAS  Google Scholar 

  • Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015;523:177–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nakato H, Futch TA, Selleck SB. The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. Development. 1995;121:3687–702.

    PubMed  CAS  Google Scholar 

  • Okamoto K, Tokunaga K, Doi K, Fujita T, Suzuki H, Katoh T, et al. Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat Genet. 2011;43:459–63.

    Article  PubMed  CAS  Google Scholar 

  • Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, et al. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat Genet. 1996;12:241–7.

    Article  PubMed  CAS  Google Scholar 

  • Song YS, Kim E. Presynaptic proteoglycans: sweet organizers of synapse development. Neuron. 2013;79:609–11.

    Article  PubMed  CAS  Google Scholar 

  • Stipp CS, Litwac ED, Lander AD. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. J Cell Biol. 1994;124:149–60.

    Article  PubMed  CAS  Google Scholar 

  • Svensson G, Awad W, Hakansson M, Mani K, Logan DT. Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionary conserved in vertebrate glypican-1. J Biol Chem. 2012;287:14040–51.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wilson NH, Stoeckli ET. Sonic hedgehog regulates its own receptor on postcrossing commissural axons in a glypican1-dependent manner. Neuron. 2013;79:478–91.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada

    Jorge Filmus

Authors
  1. Jorge Filmus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jorge Filmus .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Filmus, J. (2018). Glypicans (GPCs). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101637

Download citation

Publish with us

Policies and ethics

Search

Navigation