Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Glypicans (GPCs)

  • Jorge Filmus
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101637

Synonyms

 Glypican-1: Glypican; Glypican 1; Glypican-1; GPC1

 Glypican-2: Glypican 2; Glypican-2; GPC2; Cerebroglycan

 Glypican-3: Glypican 3; Glypican-3; GPC3; MXR7; OCI-5

 Glypican-4: Glypican 4; Glypican-4; GPC4; K-glypican

 Glypican-5: Glypican 5; Glypican-5; GPC5

 Glypican-6: Glypican 6; Glypican-6; GPC6

Historical Background

Glypican-3 (GPC3) is the first glypican that was cloned (Filmus et al. 1988). Initially named OCI-5, GPC3 was identified in 1988 as a gene whose expression was developmentally regulated in the intestine. Two years later, the cloning of Glypican-1 (GPC1) was reported. This report characterized GPC1 as a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan (HSPG), but it did not indicate that GPC1 displays significantly homology with GPC3 (David et al. 1990). This homology was noticed 4 years later in a study that reported the cloning of Glypican-2 (initially called cerebroglycan) (Stipp et al. 1994). This study established for the first...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Sunnybrook Research InstituteUniversity of TorontoTorontoCanada