Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

GABA (γ-Aminobutyric Acid)

  • Vlainic Josipa
  • Jazvinscak Jembrek Maja
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101632

Synonyms

Historical Background

For a long time, GABA (Fig. 1) was known only as a product of plant and microbial metabolism. It was first synthesized in 1883, and in 1950 it was realized that GABA is present in the mammalian central nervous system. As an inhibitory neurotransmitter, GABA was recognized in 1967 in experiments showing that nerve and muscle cells challenged by GABA undergo ion-mediated changes in conductance similar to those found following activation of inhibitory neurons (for review see Dreifuss et al. 1969). In the following years, dictinct roles, as well as biosynthetic and metabolic pathways of GABA were described, and its place of synthesis determined.
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Molecular MedicineRudjer Boskovic InstituteZagrebCroatia
  2. 2.Department of PsychologyCatholic University of CroatiaZagrebCroatia