Synonyms
Historical Background
Filamin A was initially discovered in 1975 as a 280 kDa actin-binding protein in rabbit alveolar macrophages (Hartwig and Stossel 1975), and was named Actin-Binding Protein 280 (ABP280). In the same year, Wang and colleagues described a high-molecular-weight nonmuscle actin-binding protein in chicken gizzard extracts and called it filamin because it was localized on actin filaments (Wang et al. 1975). The suspicion that ABP280 and filamin were the same protein was confirmed 15 years later with the cloning of the ABP280/filamin gene (Gorlin et al. 1993). Today we know that mammals have three filamins; in addition to filamin A (gene symbol FLNA, chromosome Xq28), two other genes with high homology to filamin A were cloned in 1998 and 2000, respectively called filamin β and FLN2 (Takafuta et al. 1998, Thompson et al. 2000). FLNA is the most broadly expressed...
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Baldassarre M, Razinia Z, Brahme NN, Buccione R, Calderwood DA. Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells. J Cell Sci. 2012;125(Pt 16):3858–69.
Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA. Filamins regulate cell spreading and initiation of cell migration. PLoS One. 2009;4(11):e7830.
Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009;18(24):4791–800.
Clayton-Smith J, Walters S, Hobson E, Burkitt-Wright E, Smith R, Toutain A, et al. Xq28 duplication presenting with intestinal and bladder dysfunction and a distinctive facial appearance. Eur J Hum Genet. 2009;17(4):434–43.
Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011;478(7368):260–3.
Gorlin JB, Henske E, Warren ST, Kunst CB, D’Urso M, Palmieri G, et al. Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. Genomics. 1993;17(2):496–8.
Hartwig JH, Stossel TP. Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages. J Biol Chem. 1975;250(14):5696–705.
Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, et al. The molecular basis of filamin binding to integrins and competition with talin. Mol Cell. 2006;21(3):337–47.
Kyndt F, Gueffet JP, Probst V, Jaafar P, Legendre A, Le Bouffant F, et al. Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy. Circulation. 2007;115(1):40–9.
Lad Y, Kiema T, Jiang P, Pentikainen OT, Coles CH, Campbell ID, et al. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 2007;26(17):3993–4004.
McGrath MJ, Binge LC, Sriratana A, Wang H, Robinson PA, Pook D, et al. Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer. Cancer Res. 2013;73(16):5066–79.
Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007;179(5):1011–25.
Nakamura F, Stossel TP, Hartwig JH. The filamins: organizers of cell structure and function. Cell Adhes Migr. 2011;5(2):160–9.
Razinia Z, Makela T, Ylanne J, Calderwood DA. Filamins in mechanosensing and signaling. Annu Rev Biophys. 2012;41:227–46.
Robertson SP. Filamin A: Phenotypic diversity. Curr Opin Genet Dev. 2005;15(3):301–7.
Rognoni L, Most T, Zoldak G, Rief M. Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin. Proc Natl Acad Sci USA. 2014;111(15):5568–73.
Ruskamo S, Gilbert R, Hofmann G, Jiang P, Campbell ID, Ylanne J, et al. The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended. Biochem J. 2012;446(2):261–9.
Takafuta T, Wu G, Murphy GF, Shapiro SS. Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha. J Biol Chem. 1998;273(28):17531–8.
Thompson TG, Chan YM, Hack AA, Brosius M, Rajala M, Lidov HG, et al. Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein. J Cell Biol. 2000;148(1):115–26.
Wang K, Ash JF, Singer SJ. Filamin: A new high-molecular-weight protein found in smooth muscle and non-muscle cells. Proc Natl Acad Sci USA. 1975;72(11):4483–6.
Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, et al. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010;207(11):2421–37.
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Baldassarre, M., Calderwood, D.A. (2018). Filamin A. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101630
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101630
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