Tenascin-C (TNC, Tnc)
Tenascins are extracellular matrix glycoproteins with subunits composed of epidermal growth factor (EGF)-like repeats, fibronectin type III (FNIII) domains, and a C-terminal fibrinogen-related domain (Chiquet-Ehrismann and Tucker 2011). Tenascins trimerize via heptad repeats found near their N-terminus, and, in at least some cases, two tenascin trimers can form a hexabrachion. In most vertebrates there are four paralogous tenascins: tenascin-C, tenascin-R, tenascin-W, and tenascin-X. The best studied and first to be discovered is tenascin-C, which was independently identified as an antigen or extract in tumors, tendons, muscles, bones, and developing brain. The name tenascin was adopted for this protein by Chiquet-Ehrismann and colleagues from the Latin verbs tenere (to hold) and nasci(to be born) reflecting its prominent...
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