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Encyclopedia of Signaling Molecules pp 1654–1657Cite as

ETS

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Synonyms

E26 transformation-specific family; ETS transcription factor; ETS-domain transcription factor; E-twenty-six transcription factor

Historical Background

The ETS family is one of the largest families of transcriptional regulators, which was initially derived from the leukemia virus, E26 (E-twenty-six). This virus carried the v-ets oncogene, which was initially discovered as part of the gag-myb-ets transforming fusion protein of E26 and it can cause mixed erythroid-myeloid and lymphoid leukemia. The founding member of this family is Ets1. Based on their homology with highly conserved DNA-binding domain, the ETS domain, many other ETS-domain proteins have been identified from various organisms (Sharrocks 2001). The number of ETS transcription factors is much more in vertebrates compared to invertebrate metazoans: while in Drosophila and Caenorhabditis elegans, 8 and 10 genes, respectively, are present, in vertebrates 26 or more members of this family have been found (Hart et al. 2000...

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References

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Author information

Authors and Affiliations

  1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Siences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China

    Lu Wang & Feng Liu

Authors
  1. Lu Wang
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  2. Feng Liu
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Corresponding author

Correspondence to Lu Wang .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Cite this entry

Wang, L., Liu, F. (2018). ETS. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101619

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