Reference work entry
E-cadherin is a member of the cadherin family, a family of transmembrane glycoproteins responsible for calcium-dependent cell adhesion that are the key structural components of adherens junctions (AJs). E-cadherin is encoded by CDH1 gene that localizes at 16q22.1 and composes of 18 exons. E-cadherin protein presents in epithelial tissues and composes of a single-pass transmembrane region, a cytoplasmic region, and an ectoregion that consisted of five tandemly repeated subdomains, each harboring two conserved regions representing the putative calcium binding sites (van Roy and Berx 2008). The extracellular domain of E-cadherin within one cell formed X-shaped cis dimmers, and the trans dimmer “Zipper” formed between multiple X-shaped cis dimmers of adjacent cells is the molecular basis of cell-cell adhesion (van Roy and Berx 2008). The intracellular domain of E-cadherin contains a highly phosphorylated region vital...
- Tong Z, Chakraborty S, Sung B, Koolwal P, Kaur S, Aggarwal BB, et al. Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells. Cancer. 2011;117:2408–18. https://doi.org/10.1002/cncr.25803.CrossRefPubMedGoogle Scholar
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