Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

RBR E3 Ubiquitin Ligases

  • Steven A. Beasley
  • Yaya Wang
  • Donald E. SprattEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101592


Human RBR E3 Ubiquitin Ligase Family Members

ANKIB1 (KIAA0708/KIAA1386), ARA54 (TRIAD2/RNF14/HFB30/HRIHFB2038), Dorfin (IBRDC3/RNF19), HHARI (Ariadne-1/H7-AP2/MOP-2/ARIH1), HOIL-1 (RBCK1/C20orf18/RNF54/XAP3/XAP4), HOIP (PAUL/RNF31/ZIBRA), Parc (Cullin-9/CUL-9, H7AP1), Parkin (Prkn/Park2), RNF144A (KIAA0161)/UBCE7IP4), RNF144B (p53RFP/PIR2/IBRDC2), RNF19B (IBRDC3/NKLAM), RNF217 (C6orf172/IBRDC1), TRIAD1 (Ariadne-2), TRIAD3 (RNF216/ZIN).

Historical Background

The RBR E3 ligase family, comprised of two conserved zinc-binding RING-like domains surrounding a novel zinc-binding motif, was originally identified independently by two research groups. This newly recognized zinc-binding motif was named DRIL (double RING finger linked), as it was exclusively found between two conserved RING-like sequences, and the supradomain was named TRIAD (two RING fingers and a DRIL) (van der Reijden et al. 1999)....
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Steven A. Beasley
    • 1
  • Yaya Wang
    • 1
  • Donald E. Spratt
    • 1
    Email author
  1. 1.Gustaf H. Carlson School of Chemistry and BiochemistryClark UniversityWorcesterUSA