Reference work entry
Although the Ebers papyrus from ancient Egypt (1850 BC), the oldest preserved medical text, includes the first record of the use of plant remedies from the bark of poplar trees for the treatment of pain and fever, it was not until 1800s that the antipyretic and analgesic effects of willow bark was known to be originated from the active component, salicin. Later on, Kolbe and Lautemann developed a highly efficient method for the synthesis of salicylic acid from phenol. In 1897, “aspirin” was developed by Bayer Company and distributed in the general population as an antiseptic and antipyretic. Despite the wide use of nonsteroidal anti-inflammatory drug (NSAID) over the last century, the mechanism of action was not fully understood until 1971, when Vane, an awardee of Nobel Prize in physiology and medicine in 1982, showed that NSAIDs inhibited the enzyme...
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