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BTK, Table 1 Btk is involved in signaling pathways downstream of various receptors on different immune cell types

From: BTK

Receptor pathway

Cell type(s)

Pre-BCR

Pre-B cells

BCR

B cells

CXCR4

Pre-B, B cells

CD38

Activated B cells

Epo-R

Erythrocytes

TRAIL-R1

Erythrocytes

FcεR

Mast cells, basophils

FCγR

Myeloid cells

GPVI

Platelets

IL-5R

B cells, eosinophils, basophils

IL-6R

Activated B cells, plasma cells

TLR

Myeloid cells, B cells

M-CSFR

Macrophages

CD303 (BDCA-2)

Plasmacytoid dendritic cells

HGF/c-MET

Dendritic cells

fMLFR

Neutrophils

  1. R receptor, Epo erythropoietin, GPVI collagen receptor glycoprotein VI, IL interleukin, TLR toll-like receptor, TRAIL tumor necrosis factor (TNF)-related apoptosis-inducing ligand, HGF hepatocyte growth factor, fMLFR formyl-methionyl-leucyl-phenylalanine receptor