Small GTPases belonging to Ras super family transmit extracellular signals to regulate multiple cellular functions. These proteins are inactive when they are bound to GDP and are active when bound to GTP, thereby acting as molecular switches. Conversion of GTPases from inactive GDP bound form to active GTP bound form is performed by GTP exchange factors (GEFs). GEFs are important hubs in pathways that integrate upstream signals to activate small GTPases, eventually translating the signals into required cellular functions.
C3G is a GEF having CDC25 homology domain characteristic to GEFs for Ras family GTPases. C3G was discovered as a Crk interacting protein that binds to SH3 domain of Crk and GRB2 in 1994 (Tanaka et al. 1994). Another study published in the same year also identified C3G as a...