Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Orexin Receptor-1 (OX1R)

  • Omkar L. PatkarEmail author
  • Arnauld Belmer
  • Selena E. Bartlett
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101540


Historical Background

Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers. One group named it orexin after the Greek word orexis which means “appetite,” while the other group named it hypocretin since it was synthesized in the hypothalamus and resembles secretin (Sakurai et al. 1998). Both the nomenclatures for orexins are currently in use. We would adhere to “orexin” for references to the peptides in this article.

These hypothalamic peptides are produced by orexin neurons in the dorsomedial (DMH), lateral (LH), and perifornical hypothalamic areas (PFA) (Sakurai et al. 1998). Since these areas of the hypothalamus are involved in arousal, sleep-wake cycle, thermoregulation, feeding and appetite, the function of orexins is implicated in the regulation of these behaviors. Furthermore, studies have shown that...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Omkar L. Patkar
    • 1
    Email author
  • Arnauld Belmer
    • 2
  • Selena E. Bartlett
    • 3
  1. 1.Translational Research Institute (TRI)Queensland University of Technology (QUT)BrisbaneAustralia
  2. 2.Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT)BrisbaneAustralia
  3. 3.Queensland University of Technology (QUT)BrisbaneAustralia