Historical Background
S100A6 belongs to the S100 family of Ca2+-binding proteins of the EF-hand type (reviewed in Donato et al. 2013). As a member of the A group of S100 proteins, human S100A6 gene maps to chromosome 1q21. S100A6 is expressed as an 89-amino-acid protein in mouse and rat and a 90-amino-acid protein in human and rabbit. Two chicken isoforms, A (92 amino acids) and B (91 amino acids), probably result from alternative mRNA splicing. S100A6 from all these sources differs in only a few amino acids and in the length of the carboxy terminus. The S100A6 gene was initially identified in growth-arrested rodent fibroblasts stimulated with serum and suggested to have a role in cell-cycle progression as inferred by its upregulation in several tumors (reviewed in Leśniak et al. 2009). S100A6 was found to interact with...
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Botelho HM, Leal SS, Cardoso I, Yanamandra K, Morozova-Roche LA, Fritz G, Gomes CM. S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation. J Biol Chem. 2012;287:42233–42.
Cai XY, Lu L, Wang YN, Jin C, Zhang RY, Zhang Q, Chen QJ, Shen WF. Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury. Atherosclerosis. 2011;217:536–42.
Chen H, Xu C, Jin Q, Liu Z. S100 protein family in human cancer. Am J Cancer Res. 2014;4:89–115.
Chen X, Liu X, Lang H, Zhang S, Luo Y, Zhang J. S100 calcium-binding protein A6 promotes epithelial-mesenchymal transition through β-catenin in pancreatic cancer cell line. PLoS One. 2015;10:e0121319.
Donato R, Cannon BR, Sorci G, Riuzzi F, Hsu K, Weber DJ, Geczy CL. Functions of S100 proteins. Curr Mol Med. 2013;13:24–57.
Graczyk A, Leśniak W. S100A6 expression in keratinocytes and its impact on epidermal differentiation. Int J Biochem Cell Biol. 2014;57:135–41.
Graczyk A, Słomnicki LP, Leśniak W. S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation. J Mol Biol. 2013;425:3488–94.
Jurewicz E, Góral A, Filipek A. S100A6 is secreted from Wharton’s jelly mesenchymal stem cells and interacts with integrin β1. Int J Biochem Cell Biol. 2014;55:298–303.
Leśniak W, Słomnicki ŁP, Filipek A. S100A6 – new facts and features. Biochem Biophys Res Commun. 2009;390:1087–92.
Li Y, Wagner ER, Yan Z, Wang Z, Luther G, Jiang W, Ye J, Wei Q, Wang J, Zhao L, Lu S, Wang X, Mohammed MK, Tang S, Liu H, Fan J, Zhang F, Zou Y, Song D, Liao J, Haydon RC, Luu HH, He TC. The calcium-binding protein S100A6 accelerates human osteosarcoma growth by promoting cell proliferation and inhibiting osteogenic differentiation. Cell Physiol Biochem. 2015;37:2375–92.
Lyu XJ, Li HZ, Ma X, Li XT, Gao Y, Ni D, Shen DL, Gu LY, Wang BJ, Zhang Y, Zhang X. Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma. Oncotarget. 2015;6:6656–69.
Mohan SK, Gupta AA, Yu C. Interaction of the S100A6 mutant (C3S) with the V domain of the receptor for advanced glycation end products (RAGE). Biochem Biophys Res Commun. 2013;434:328–33.
Nishi M, Matsumoto K, Kobayashi M, Yanagita K, Matsumoto T, Nagashio R, Ishii D, Fujita T, Sato Y, Iwamura M. Serum expression of S100A6 is a potential detection marker in patients with urothelial carcinoma in the urinary bladder. Biomed Res. 2014;35:351–6.
Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R. Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. Structure. 2002;10:557–67.
Tamai H, Miyake K, Yamaguchi H, Shimada T, Dan K, Inokuchi K. Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice. Bone Marrow Transplant. 2014;49:699–703.
Tsoporis JN, Marks A, Haddad A, O’Hanlon D, Jolly S, Parker TG. S100A6 is a negative regulator of the induction of cardiac genes by trophic stimuli in cultured rat myocytes. Exp Cell Res. 2005;303(2):471–8.
Wang T, Liang Y, Thakur A, Zhang S, Yang T, Chen T, Gao L, Chen M, Ren H. Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer. Tumour Biol. 2016;37:2299–304.
Wasik U, Kadziolka B, Kilanczyk E, Filipek A. Influence of S100A6 on CacyBP/SIP phosphorylation and Elk-1 transcriptional activity in neuroblastoma NB2a cells. Cell Biochem. 2016;117:126–31.
Yamada J, Jinno S. S100A6 (calcyclin) is a novel marker of neural stem cells and astrocyte precursors in the subgranular zone of the adult mouse hippocampus. Hippocampus. 2014;24:89–101.
Zhang J, Zhang K, Jiang X, Zhang J. S100A6 as a potential serum prognostic biomarker and therapeutic target in gastric cancer. Dig Dis Sci. 2014;59:2136–44.
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Donato, R., Sorci, G., Giambanco, I. (2018). S100A6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101531
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101531
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