Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Yang Liu
  • Hong-Long JiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101527


Historical Background

The active transport of sodium in epithelial tissue has been stated since 1950s (Leaf et al. 1958). In 1962, scientists found that the movement of Na+ from the liquid of lumen side into epithelial cell was not in the manner of free diffusion, but was possibly driven by electrical forces through the interaction with a saturable permease on the plasma membrane (Frazier 1962; Frazier et al. 1962; Park and Fanestil 1980). In 1970s, this permease was found to be the target of amiloride, the specific blocker of epithelial Na+ channel (ENaC), and active as a channel rather than a carrier (Lindemann and Van Driessche 1977; Park and Fanestil 1980). Epithelial Na+channel (ENaC) was characterized...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute of Lung and Molecular TherapyXinxiang Medical UniversityXinxiang, HenanChina
  2. 2.Department of Cellular and Molecular BiologyUniversity of Texas Health Science Center at TylerTylerUSA