RIAM (Rap1-Interactive Adaptor Molecule)
RIAM was identified in a search of new effector molecules of the small guanosine triphosphatase (GTPase) Rap1, using the yeast two-hybrid system screen. Due to its interaction with Rap1, the newly identified Rap1-interacting effector was named RIAM (Rap1-interacting adaptor molecule) (Lafuente et al. 2004). Before its identification as a Rap1-interacting molecule, RIAM was found as a binding partner of the amyloid beta (A4) precursor protein-binding, family B, member 1 (APBB1) – also known as neural Fe65 protein – and was termed amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (APBB1IP) (Ermekova et al. 1997). In an independent study, RIAM was identified as a protein whose expression was induced in response to all-transretinoic...
This work was supported by NIH grants CA183605, CA183605S1, and AI098129-01 and the DoD grant PC140571 (VAB), SAF2012-34561, and SAF2016-77096- R (EML).
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