Synonyms
Historical Background
The accuracy of cell division is fundamental for the maintenance of cell ploidy and genomic stability. During cell division, many events, like DNA replication, chromosome segregation, mitosis completion, and cytokinesis, must be tightly controlled. The deregulation of these events is closely associated with severe pathology. Among other factors, the accuracy of cell division relies on the correct placement of the division plane which is dependent on the polarity axis (Lu and Johnston 2013).
Both in unicellular organisms and in metazoan, the cell spindle position is regulated to be perpendicular or planar to the division plane, allowing this way to equally segregate the chromosomes between the two daughter cells. In either case, the correct position/orientation of the spindle is required to maintain cell architecture and tissues homeostasis, events that are on the origin of...
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References
Caydasi AK, Ibrahim B, Pereira G. Monitoring spindle orientation: Spindle position checkpoint in charge. Cell Div. 2010;5:28. https://doi.org/10.1186/1747-1028-5-28.
Chalker DL, Frankel J. Morphogenesis: A mob rules from the rear. Curr Biol. 2014;24:R700–2. https://doi.org/10.1016/j.cub.2014.06.042.
Chow A, Hao Y, Yang X. Molecular characterization of human homologs of yeast MOB1. Int J Cancer. 2010;126:2079–89. https://doi.org/10.1002/ijc.24878.
Fallahi E, O’Driscoll N, Matallanas D. The MST/Hippo pathway and cell death: A non-canonical affair. Genes. 2016;7:28. https://doi.org/10.3390/genes7060028.
Florindo C, Perdigao J, Fesquet D, Schiebel E, Pines J, Tavares AA. Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. J Cell Sci. 2012;125:3085–90. https://doi.org/10.1242/jcs.097147.
Galla G, Zenoni S, Marconi G, Marino G, Botton A, Pinosa F, et al. Sporophytic and gametophytic functions of the cell cycle-associated Mob1 gene in Arabidopsis thaliana L. Gene. 2011;484:1–12. https://doi.org/10.1016/j.gene.2011.05.009.
Halaoui R, McCaffrey L. Rewiring cell polarity signaling in cancer. Oncogene. 2014;34:1–12. https://doi.org/10.1038/onc.2014.59.
Hammarton TC, Lillico SG, Welburn SC, Mottram JC. Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis. Mol Microbiol. 2005;56:104–16. https://doi.org/10.1111/j.1365-2958.2005.04542.x.
Hergovich A. MOB control : reviewing a conserved family of kinase regulators. Cell Signal. 2011;23:1433–40. https://doi.org/10.1016/j.cellsig.2011.04.007.MOB.
Hergovich A, Hemmings BA. Hippo signalling in the G2 / M cell cycle phase : Lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol. 2012;23:794–802. https://doi.org/10.1016/j.semcdb.2012.04.001.
Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, et al. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 2011;30:1520–35. https://doi.org/10.1038/emboj.2011.63.
Lai Z-C, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 2005;120:675–85. https://doi.org/10.1016/j.cell.2004.12.036.
Lu MS, Johnston CA. Molecular pathways regulating mitotic spindle orientation in animal cells. Development. 2013;140:1843–56. https://doi.org/10.1242/dev.087627.
Luca FC, Mody M, Kurischko C, Roof MD, Gidding TH, Winey M. Saccharomyces cerevisiae Mob1p Is Required for Cytokinesis and Mitotic Exit. Microbiology. 2001;21:6972–83. https://doi.org/10.1128/MCB.21.20.6972.
Luca FC, Winey M. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol Biol Cell. 1998;9:29–46.
Pinosa F, Begheldo M, Pasternak T, Zermiani M, Paponov IA, Dovzhenko A, et al. The Arabidopsis thaliana Mob1A gene is required for organ growth and correct tissue patterning of the root tip. Ann Bot. 2013;112:1803–14. https://doi.org/10.1093/aob/mct235.
Salimova E, Sohrman M, Fournier N, Simanis V. The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signaling the onset of septum formation. J Cell Sci. 2000;113:1695–704.
Slabodnick MM, Ruby JG, Dunn JG, Feldman JL, DeRisi JL, Marshall WF. The kinase regulator Mob1 acts as a patterning protein for stentor morphogenesis. PLoS Biol 2014;12. https://doi.org/10.1371/journal.pbio.1001861.
Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, et al. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure. 2003;11:1163–70. https://doi.org/10.1016/S0969-2126(03)00182-5.
Tavares A, Goncalves J, Florindo C, Tavares AA, Soares H. Mob1: defining cell polarity for proper cell division. J Cell Sci. 2012;125:516–27. https://doi.org/10.1242/jcs.096610.
Wilmeth LJ, Shrestha S, Montano G, Rashe J, Shuster CB. Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. Mol Biol Cell. 2010;21:380–92. https://doi.org/10.1091/mbc.E09-06-0471.
Yamashita YM, Mahowald AP, Perlin JR, Fuller MT. Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science. 2007;315:518–21. https://doi.org/10.1126/science.1134910.
Yu FX, Guan KL. The Hippo pathway: regulators and regulations. Genes Dev. 2013;27:355–71. https://doi.org/10.1101/gad.210773.112.
Zeng Q, Hong W. The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals. Cancer Cell. 2008;13:188–92. https://doi.org/10.1016/j.ccr.2008.02.011.
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Carmona, B., Tavares, A., Nolasco, S., Leitão, A., Soares, H. (2018). MOB1A. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101509
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101509
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