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G alpha o

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References

  • Chamero P, Katsoulidou V, Hendrix P, Bufe B, Roberts R, Matsunami H, Abramowitz J, Birnbaumer L, Zufall F, Leinders-Zufall TG. Protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci USA. 2011;108:12898–903.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chatterjee A, Roman G, Hardin PE. Go contributes to olfactory reception in Drosophila melanogaster. BMC Physiol. 2009;9:22.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Devambez I, Ali Agha M, Mitri C, Bockaert J, Parmentier ML, Marion-Poll F, Grau Y, Soustelle L. Gαo is required for L-canavanine detection in Drosophila. PLoS ONE. 2013;8:e63484.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dhingra A, Jiang M, Wang TL, Lyubarsky A, Savchenko A, Bar-Yehuda T, Sterling P, Birnbaumer L, Vardi N. Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). J Neurosci. 2002;22:4878–84.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Garcia-Marcos M, Ghosh P, Farquhar MG. Molecular basis of a novel oncogenic mutation in GNAO1. Oncogene. 2011 Jun 9;30:2691–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hepler JR, Gilman AG. G proteins. Trends Biochem Sci. 1992;17:373–7.

    Article  Google Scholar 

  • Hofler C, Koelle MR. AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo. J Neurosci. 2011;31:11553–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Itoh H, Kozasa T, Nagata S, Nakamura S, Katada T, Ui M, Iwai S, Ohtsuka E, Kawasaki H, Suzuki K. Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986;83:3776–80.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jiang M, Bajpayee NS. Molecular mechanisms of go signaling. Neurosignals. 2009;17:23–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, Yue P, Haverty PM, Bourgon R, Zheng J, Moorhead M, Chaudhuri S, Tomsho LP, Peters BA, Pujara K, Cordes S, Davis DP, Carlton VE, Yuan W, Li L, Wang W, Eigenbrot C, Kaminker JS, Eberhard DA, Waring P, Schuster SC, Modrusan Z, Zhang Z, Stokoe D, de Sauvage FJ, Faham M, Seshagiri S. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature. 2010;466:869–73.

    Article  PubMed  CAS  Google Scholar 

  • Kasahara K, Ui M. G protein alpha o UCSD Nature Molecule Pages http://www.signalinggateway.org/molecule/query?afcsid=A000976 Published online: 10 Jan 2011|https://doi.org/10.1038/mp.a000976.01

  • Katada T, Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci U S A. 1982;79:3129–33.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Katanaev VL, Ponzielli R, Sémériva M, Tomlinson A. Trimeric G protein-dependent frizzled signaling in Drosophila. Cell. 2005;120:111–22.

    Article  PubMed  CAS  Google Scholar 

  • Lamberts JT, Smith CE, Li MH, Ingram SL, Neubig RR, Traynor JR. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. J Neurosci. 2013;33:4369–77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Masuho I, Xie K, Martemyanov KA. Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells. J Biol Chem. 2013;288:25129–42.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mendel JE, Korswagen HC, Liu KS, Hajdu-Cronin YM, Simon MI, Plasterk RH, Sternberg PW. Participation of the protein Go in multiple aspects of behavior in C. elegans. Science. 1995;267:1652–5.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H. De novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy. Am J Hum Genet. 2013;93:496–505.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Qin Y, Ji J, Du G, Wu W, Dai J, Hu Z, Sha J, Hang B, Lu C, Xia Y, Wang X. Comprehensive pathway-based analysis identifies associations of BCL2, GNAO1 and CHD2 with non-obstructive azoospermia risk. Hum Reprod. 2014;29:860–6.

    Article  PubMed  CAS  Google Scholar 

  • Yi W, Zhang Y, Tian Y, Guo J, Li Y, Guo A. A subset of cholinergic mushroom body neurons requires Go signaling to regulate sleep in Drosophila. Sleep. 2013;36:1809–21.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yuyama K, Sekino-Suzuki N, Sanai Y, Kasahara K. Translocation of activated heterotrimeric G protein Galpha(o) to ganglioside-enriched detergent-resistant membrane rafts in developing cerebellum. J Biol Chem. 2007a;282:26392–400.

    Article  PubMed  CAS  Google Scholar 

  • Yuyama K, Sekino-Suzuki N, Kasahara K. Signal transduction of heterotrimeric G proteins in lipid rafts trend. Glycosci Glycotech. 2007b;19:19–27.

    Article  CAS  Google Scholar 

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Correspondence to Kohji Kasahara .

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Iguchi, T., Kasahara, K. (2018). G alpha o. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101497

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