Synonyms
Angiofollicular lymph node hyperplasia; Angiomatous lymphoid hamartoma; Benign giant lymphoma; Giant lymph node hyperplasia
Definition
Castleman disease is a relatively rare lymphoproliferative disorder that includes a heterogeneous group of diseases with protean clinical and morphologic features. The various types of Castleman disease comprise unicentric and multicentric variants, which somewhat overlap with the hyaline vascular and plasma cell morphologic subtypes, respectively.
Clinical Features
Incidence
The prevalence of Castleman disease is not well established. There are several large case series describing different variants of the disease in immunocompetent and HIV patients, and certain data can be extracted from those studies. In the United States, it was estimated that there are between 30,000 and 100,000 cases (Casper 2005).
Age
The unicentric, hyaline vascular Castleman disease has a median age of presentation in the fourth decade, although it can occur in a range...
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References and Further Reading
Casper, C. (2005). The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol, 129(1), 3–17.
Castleman, B., & Towne, V. W. (1954). Case records of the Massachusetts General Hospital: Case No. 40231. N Engl J Med, 250(23), 1001–1005.
Castleman, B., Iverson, L., & Menendez, V. P. (1956). Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer, 9(4), 822–830.
Frizzera, G. (1988). Castleman’s disease and related disorders. Semin Diagn Pathol, 5(4), 346–364.
Peterson, B. A., & Frizzera, G. (1993). Multicentric Castleman’s disease. Semin Oncol, 20(6), 636–647.
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Olteanu, H. (2018). Castleman Disease, Mediastinal. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_8
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DOI: https://doi.org/10.1007/978-3-319-66796-6_8
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