Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

B-Cell Lymphoma, Mediastinal, Diffuse, and Large

  • Horatiu OlteanuEmail author
Reference work entry


Primary mediastinal (thymic) large B-cell lymphoma


Primary mediastinal (thymic) large B-cell lymphoma (PMLBCL) is a diffuse large B-cell lymphoma (DLBCL) of putative thymic origin, arising in the anterior mediastinum and showing distinct clinical and pathologic features (Cazals-Hatem et al. 1996; Johnson and Davies 2008).

Clinical Features

  • Incidence

    PMLBCL is an uncommon neoplasm, representing 2–4% of non-Hodgkin lymphomas and approximately 6% of all adult lymphomas.

  • Age

    Young adults are most commonly affected, with a median age of presentation of 35 years, although the age range is fairly broad (15–73 years, in a series of 29 cases).

  • Sex

    There is a female predominance (male to female = 1:2) in those diagnosed with PMLBCL.

  • Site

    Clinically, patients present with a bulky, anterior mediastinal mass, which commonly extends to the pericardium, pleura, or lung and causes superior vena cava invasion or compression. There is very rare systemic, lymph node, CNS, and bone...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Cazals-Hatem, D., Lepage, E., Brice, P., Ferrant, A., d'Agay, M. F., Baumelou, E., et al. (1996). Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (“Groupe d’Etude des Lymphomes de l’Adulte”) study. American Journal of Surgical Pathology, 20(7), 877–888.CrossRefPubMedGoogle Scholar
  2. Johnson, P. W., & Davies, A. J. (2008). Primary mediastinal B-cell lymphoma. Hematology/American Society of Hematology Education Program, 2008, 349–358.Google Scholar
  3. Rieger, M., Osterborg, A., Pettengell, R., White, D., Gill, D., Walewski, J., et al. (2011). Primary mediastinal B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: results of the Mabthera International Trial Group Study. Annals of Oncology, 22(3), 664–670.CrossRefPubMedGoogle Scholar
  4. Savage, K. J., Al-Rajhi, N., Voss, N., Paltiel, C., Klasa, R., Gascoyne, R. D., et al. (2006). Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience. Annals of Oncology, 17(1), 123–130.CrossRefPubMedGoogle Scholar
  5. Steidl, C., & Gascoyne, R. D. (2011). The molecular pathogenesis of primary mediastinal large B-cell lymphoma. Blood, 118(10), 2659–2669.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Department of Pathology, Mayo ClinicRochesterUSA