Synovial Sarcoma, Mediastinal
Primary synovial sarcoma is a distinctive mesenchymal neoplasm usually occurring in the limbs of young patients; however, intrathoracic forms are not unusual, and cases occurring in the mediastinum have been described in independent series (Hartel et al. 2007; Moran et al. 1994; Suster and Moran 2005). Although microscopically identical to synovial sarcoma arising in the somatic soft tissues, mediastinal lesions may be confused with many intrathoracic mesenchymal proliferations. In addition, mediastinal synovial sarcomas (MSSs) appear to occur in younger patients and to pursue a more aggressive course. Infiltration of the adjacent structures is common and makes radical excision of the tumor difficult.
Being very rare, with limited reported cases, the incidence of MSS is difficult to estimate. Synovial sarcoma is, however, one of the most common intrathoracic sarcomas.
Most patients were between the second and fifth decade group; however, cases...
References and Further Reading
- Terry, J., Saito, T., Subramanian, S., Ruttan, C., Antonescu, C.R., Goldblum, J.R., et al. (2007). TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies, American Journal of Surgical Pathology, 31(2), 240–246.CrossRefPubMedGoogle Scholar