Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Drug Induced Pleural Disease

  • Adam L. BoothEmail author
  • Timothy Craig Allen
Reference work entry


Drug-induced pleural disease; Drug-induced pleural fibrosis

Drug-induced pleural disease is a relatively uncommon complication compared with drug-induced lung disease. Cardiovascular agents, sclerotherapy agents, and chemotherapeutic agents have primarily been implicated in the development of pleural disease. With drug advancements, the list will likely grow. Drugs may cause pleural pathology alone or accompanying lung disease. Clinical presentation includes a variety of symptoms including asymptomatic pleural effusion, acute pleuritis, and symptomatic pleural thickening. Except for drug-induced lupus pleuritis, the pathogenesis of drug-induced pleural disease remains unknown. Suspected mechanisms include hypersensitivity or allergic reaction, direct toxic effect, increased oxygen free radical production, suppression of the antioxidant defences, and chemical-induced inflammation. In most cases, a detailed history establishing a temporal relationship between drug use and...

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References and Further Reading

  1. Alagha, K., et al. (2011). Iatrogenic eosinophilic pleural effusion. European Respiratory Review, 20(120), 118–120.CrossRefPubMedGoogle Scholar
  2. Antony, V. B. (1998). Drug-induced pleural disease. Clinics in Chest Medicine, 19(2), 331–340.CrossRefPubMedGoogle Scholar
  3. Huggins, J. T., & Sahn, S. A. (2004). Drug-induced pleural disease. Clinics in Chest Medicine, 25(1), 141–153.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Texas Medical BranchGalvestonUSA
  2. 2.Department of PathologyThe University of Mississippi Medical School, The University of Mississippi Medical CenterJacksonUSA