Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Well-Differentiated Papillary Mesothelioma, Pleural

  • Michael P. SedrakEmail author
  • Timothy Craig Allen
Reference work entry


Well-differentiated papillary mesothelioma (WDPM) of the pleura is a distinct tumor that tends to spread superficially with minimal or no invasion and has characteristic morphologic features.

Clinical Features

  • Incidence

    Pleural WDPM is rare, compared to the much more common peritoneal form, with fewer than 50 cases reported.

  • Age

    WDPM of the pleura typically presents in the sixth decade of life but may afflict patients between the third and seventh decades, in contrast with the peritoneal form which is often discovered in the fourth decade.

  • Sex

    No gender predilection has been observed in WDPM of the pleura, in contrast to those that arise in the peritoneum, where they occur much more commonly in women.

  • Site

    Pleural WDPM may affect the visceral or parietal pleura. WDPM may also involve the peritoneum, pericardium, and tunica vaginalis testis.

  • Treatment

    Limited data indicate no benefit of chemotherapy or radiotherapy in the treatment of WDPM.

  • Outcome

    Prognosis is favorable with...

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References and Further Reading

  1. Butnor, K. J., Sporn, T. A., Hammar, S. P., & Roggli, V. L. (2001). Well-differentiated papillary mesothelioma. The American Journal of Surgical Pathology, 25(10), 1304–1309.CrossRefPubMedGoogle Scholar
  2. Churg, A., Colby, T., Cagle, P., et al. (2000). The separation of benign and malignant mesothelial proliferations. American Journal of Surgical Pathology, 24, 1183–1200.CrossRefPubMedGoogle Scholar
  3. Galateau-Sallé, F., Vignaud, J. M., Burke, L., Gibbs, A., Brambilla, E., Attanoos, R., Goldberg, M., & Launoy, G. (2004). Mesopath group. Well-differentiated papillary mesothelioma of the pleura: A series of 24 cases. The American Journal of Surgical Pathology, 28(4), 534–540.CrossRefPubMedGoogle Scholar
  4. Malpica, A., Sant'Ambrogio, S., Deavers, M. T., & Silva, E. G. (2012). Well-differentiated papillary mesothelioma of the female peritoneum: A clinicopathologic study of 26 cases. The American Journal of Surgical Pathology, 36(1), 117–127.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Texas Medical BranchGalvestonUSA
  2. 2.Department of PathologyThe University of Mississippi Medical School, The University of Mississippi Medical CenterJacksonUSA