Well-Differentiated Papillary Mesothelioma, Pleural
Well-differentiated papillary mesothelioma (WDPM) of the pleura is a distinct tumor that tends to spread superficially with minimal or no invasion and has characteristic morphologic features.
Pleural WDPM is rare, compared to the much more common peritoneal form, with fewer than 50 cases reported.
WDPM of the pleura typically presents in the sixth decade of life but may afflict patients between the third and seventh decades, in contrast with the peritoneal form which is often discovered in the fourth decade.
No gender predilection has been observed in WDPM of the pleura, in contrast to those that arise in the peritoneum, where they occur much more commonly in women.
Pleural WDPM may affect the visceral or parietal pleura. WDPM may also involve the peritoneum, pericardium, and tunica vaginalis testis.
Limited data indicate no benefit of chemotherapy or radiotherapy in the treatment of WDPM.
Prognosis is favorable with...
References and Further Reading
- Galateau-Sallé, F., Vignaud, J. M., Burke, L., Gibbs, A., Brambilla, E., Attanoos, R., Goldberg, M., & Launoy, G. (2004). Mesopath group. Well-differentiated papillary mesothelioma of the pleura: A series of 24 cases. The American Journal of Surgical Pathology, 28(4), 534–540.CrossRefPubMedGoogle Scholar