Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Epithelial Diffuse Malignant Mesothelioma, Pleural

  • Andrea Valeria ArrossiEmail author
Reference work entry


Epithelioid mesothelioma


Epithelial mesothelioma is a histologic type of malignant mesothelioma and is characterized by the presence of “epithelioid” cells, i.e., large polygonal cells with ample eosinophilic cytoplasm. Malignant mesotheliomas in general are the most common primary malignant neoplasm of the serosal membranes, and the epithelial type is the most common, comprising about 80% of the three recognized types of mesothelioma, epithelial, sarcomatoid, and biphasic. Asbestos exposure, radiation therapy, simian virus 40, and genetic susceptibility have been identified as risk factors for malignant mesothelioma. However, no data are available regarding the risk factors for epithelial mesothelioma over the other types. Exposure to asbestos can occur in occupations such as construction work, shipyard work, heating trades, asbestos mining, and insulation work; these occupations have relative risks for the development of malignant mesothelioma, ranging from 2.6 to...

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References and Further Reading

  1. Galateau-Salle, F. (Ed.). (2006). International mesothelioma panel. Pathology of malignant mesothelioma. London: Springer.Google Scholar
  2. Husain, A. N., Colby, T., Ordonez, N., et al. (2013). Guidelines for pathologic diagnosis of malignant mesothelioma. 2012 update of the consensus statement interest group. Archives of Pathology and Laboratory Medicine, 137, 647–667.CrossRefPubMedGoogle Scholar
  3. Ordonez, N. G. (2013). Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: A review and update. Human Pathology, 44, 1–19.CrossRefPubMedGoogle Scholar
  4. Richards, W. G., Godleski, J. J., & Yeap, B. Y. (2010). Proposed adjustments to pathologic staging of epithelial malignant pleural mesothelioma based on analysis of 354 cases. Cancer, 116(6), 1510–1517.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Cleveland ClinicClevelandUSA