Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Calcifying Fibrous Pseudotumor

Reference work entry




Calcifying fibrous pseudotumor (CFP) is an extremely rare benign fibrous lesion that was originally described by Rosenthal and Abdul-Karim as “childhood fibrous tumor with psammoma bodies” in 1988, and the term itself was introduced by Fetsch and associates with an analysis of 10 cases in 1993. In the new classification system by the World Health Organization in 1999, CFP was classified as a soft tissue tumor. CFP has its unique histopathologic features characterized by a dense hyalinized collagenous tissue interspersed with benign spindle cells, chronic inflammatory cells infiltrate, and psammomatous and/or dystrophic calcifications. CFP most commonly arises in the extremities, followed by the trunk, inguinal and scrotal regions, and the head and neck. Rare cases have been reported in the mediastinum, pleura, and visceral peritoneum. In the newly published Classification of Tumors of the Lung, Pleura, Thymus, and Heartby the World Health...

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References and Further Reading

  1. Fetsch, J. F., Montgomery, E. A., & Meis, J. M. (1993). Calcifying fibrous pseudotumor. American Journal of Surgical Pathology, 17, 502–508.CrossRefPubMedGoogle Scholar
  2. Hill, K. A., Gonzalez-Crussi, F., & Chou, P. M. (2001). Calcifying fibrous pseudotumor versus inflammatory myofibroblastic tumor: A histological and immunohistochemical comparison. Modern Pathology, 14, 784–790.CrossRefPubMedGoogle Scholar
  3. Rosenthal, N. S., & Abdul-Karim, F. W. (1988). Childhood fibrous tumor with psammoma bodies. Clinicopathologic features in two cases. Archives of Pathology and Laboratory Medicine, 112, 798–800.PubMedGoogle Scholar
  4. Suh, J. H., Shin, O. R., & Kim, Y. H. (2008). Multiple calcifying fibrous pseudotumor of the pleura. Journal of Thoracic Oncology, 3, 1356–1358.CrossRefPubMedGoogle Scholar
  5. Van Dorpe, J., Ectors, N., Geboes, K., D’Hoore, A., & Scoit, R. (1999). Is calcifying fibrous pseudotumor a late sclerosing stage of inflammatory myofibroblastic tumor? American Journal of Surgical Pathology, 23, 329–335.CrossRefPubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Texas Medical Branch301 University Blvd GalvestonUSA