Pleural type; Pulmonary amyloidosis
Pleural amyloidosis is the deposition of amyloid protein into the visceral or parietal pleura. Amyloid refers to misfolded proteins with a beta-pleated sheet conformation forming insoluble fibrils that accumulate in various organs. Amyloid buildup mechanically disrupts the involved tissue parenchyma and interferes with many cellular processes occurring within the cellular microenvironment. The extent of pathophysiological disturbances due of amyloid is still incompletely understood.
Over 20 types of proteins accompanying different diseases can result in amyloid formation. The most commonly involved misfolded fibril proteins are AL, AA, ATTR, and Aβ amyloid. AL amyloid is derived from excess light-chain immunoglobulins associated with plasma cells dyscrasias: most notably multiple myeloma. The precursor protein of AA amyloid is serum amyloid A (SAA) proteins, a subset of apolipoproteins, which are acute phase reactants elevated in...
References and Further Reading
- 2.Gertz, M. A., Buadi, F. K., Zeldenrush, S. R., & Hayman, S. R. (2013). Chapter 87: Immunoglobulin light-chain amyloidosis (Primary amyloidosis). In R. Hoffman, E. J. Benz Jr., L. E. Silberstein, E. H. Helen, & J. I. Weitz (Eds.), Hematology: Basic principles and practice (6th ed., pp. 1350–1373). Philadelphia, PA: Saunders, and imprint of Elsevier.Google Scholar