Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Acquired Multilocular Thymic Cyst

  • Luka BrcicEmail author
Reference work entry


Acquired multilocular thymic cysts are multilocular lesions with epithelial lining and with thymic tissue in the cyst walls. They are found in the neck and mediastinum and, as suggested by Suster and Rosai in 1991, most probably develop as a result of acquired inflammatory processes leading to cystic transformation of structures derived from medullary duct epithelium. Another possible cause can be dysregulation of immune system, since they have been described in children and adults in association with human immunodeficiency virus infection.

Clinical Features

  • Incidence

    Acquired multilocular thymic cysts are extremely rare, even rarer than congenital thymic cysts which are rare lesions.

  • Age

    Acquired multilocular thymic cyst can occur at any age.

  • Sex

    There is no predilection for either sex.

  • Site

    Acquired multilocular thymic cysts occur most commonly in the anterosuperior mediastinum and neck.

  • Treatment

    Surgical excision if symptomatic.

  • Outcome

    Acquired multilocular thymic cysts...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Kontny, H. U., Sleasman, J. W., Kingma, D. W., Jaffe, E. S., Avila, N. A., Pizzo, P. A., & Mueller, B. U. (1997). Multilocular thymic cysts in children with human immunodeficiency virus infection: Clinical and pathologic aspects. Journal of Pediatrics, 131, 264–270.CrossRefPubMedGoogle Scholar
  2. Morikawa, H., Tanaka, T., Hamaji, M., Ueno, Y., & Hara, A. (2010). Papillary adenocarcinoma developed in a thymic cyst. General Thoracic and Cardiovascular Surgery, 58, 295–297.CrossRefPubMedGoogle Scholar
  3. Shi, X., Nasseri, F., Berger, D. M., & Nachiappan, A. C. (2012). Large multilocular thymic cyst: A rare finding in an HIV positive adult female. Journal of Clinical Imaging Science, 2, 55.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Shimosato, Y., Mukai, K., & Matsuno, Y. (2010). Thymic cyst. In S. G. Silverberg (Ed.), AFIP Atlas of tumor pathology. Tumors of the mediastinum (pp. 263–265). Washington, DC: American Registry of Pathology.Google Scholar
  5. Suster, S., & Rosai, J. (1991). Multilocular thymic cyst: An acquired reactive process. Study of 18 cases. American Journal of Surgical Pathology, 15, 388–398.CrossRefPubMedGoogle Scholar
  6. Suster, S., Barbuto, D., Carlson, G., & Rosai, J. (1991). Multilocular thymic cysts with pseudoepitheliomatous hyperplasia. Human Pathology, 22, 455–460.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of PathologyMedical University of GrazGrazAustria