Embryonal Carcinoma, Mediastinal
Malignant germ cell tumor composed of primitive appearing markedly atypical epithelial tumor cells.
Rare. Pure embryonal carcinoma constitutes approximately 7% of malignant germ cell tumors of the mediastinum and may be seen as a component in mixed malignant germ cell tumors. If teratoma is also considered, the incidence of embryonal carcinoma is around 1.9% of all germ cell tumors.
Mean age at presentation: 30–40 years.
Almost exclusive male predominance.
Anterior mediastinum in association with thymus putatively from extragonadal germ cells or thymic cells with germ cell potential. Its primary nature in the mediastinum was confirmed by Cox in post-mortem examination testis in men with primary mediastinal germ cell tumors which failed to reveal testicular neoplastic pathology. However, in a patient presenting with embryonal carcinoma diagnosed as mediastinal mass, a thorough work up should be done to...
References and Further Reading
- Moran, C. A., Suster, S., & Koss, M. N. (1997). Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum – A clinicopathologic and immunohistochemical study of 64 cases. Cancer, 80(4), 699–707.CrossRefPubMedGoogle Scholar