Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Chondrosarcoma, Mediastinal

  • Giovanni FalconieriEmail author
Reference work entry


Chondrosarcoma is a malignant tumor composed of cells that produce a cartilaginous ground substance. Although mostly documented in bones of the axial skeleton including those of the thoracic cage, occurrence in extraskeletal locations such as the somatic or visceral soft parts has been reported.

In the mediastinum, chondrosarcoma is considered very rare (Macchiarini and Ostertag 2004; Suster and Moran 1997). It has been postulated that these tumors may arise from cartilaginous elements within teratomatous lesions or from displaced connective tissue during embryogenesis or embryonic somatic remnants. Histologically, mediastinal chondrosarcoma (MCS) is comparable with its bony counterpart; however, the clinical, biological, and genetic changes differ. Depending on the degree of compression or invasion of intrathoracic organs, symptoms vary and include chest pain, shortness of breath, and dysphagia. Cases discovered incidentally during work-up of other conditions have been...
This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Macchiarini, P., & Ostertag, H. (2004). Uncommon primary mediastinal tumours. Lancet Oncology, 5(2), 107–118.CrossRefPubMedGoogle Scholar
  2. Suster, S., & Moran, C. A. (1997). Malignant cartilaginous tumors of the mediastinum: Clinicopathological study of six cases presenting as extraskeletal soft tissue masses. Human Pathology, 28(5), 588–594.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology, School of MedicineUniversity of TriesteTriesteItaly