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Myeloid-Derived Suppressor Cells in Aged Humans

  • Michael J. Rauh
  • Elina K. Cook
  • Dawn M.E. Bowdish
Living reference work entry

Abstract

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells whose immunosuppressive activities contribute to cancer and other diseases. MDSCs appear to increase with age, and this presumably contributes to immunosuppression and the increased incidence of certain diseases. Why MDSCs increase with age is not entirely clear. Herein we present evidence that MDSC expansion is due in part to age-related changes in hematopoiesis, including the acquisition of mutations that favor myelopoiesis, which are compounded by changes in the aging microenvironment that favor the production of MDSCs.

Keywords

Immunosenescence Myeloid-derived suppressor cells Inflammation Myelodysplastic disorders Myelopoiesis 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Michael J. Rauh
    • 1
  • Elina K. Cook
    • 1
    • 2
  • Dawn M.E. Bowdish
    • 3
    • 4
  1. 1.Department of Pathology and Molecular Medicine, Richardson LaboratoryQueen’s UniversityKingstonCanada
  2. 2.School of Medicine, Faculty of Health SciencesQueen’s UniversityKingstonCanada
  3. 3.McMaster Immunology Research CentreHamiltonCanada
  4. 4.M.G. DeGroote Institute for Infectious Disease ResearchHamiltonCanada

Section editors and affiliations

  • Tamas Fulop
    • 1
  1. 1.Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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