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Handbook of Immunosenescence pp 1–15Cite as

Age-Related Dysfunction in the Innate Immune Response to Lung Infections

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Abstract

Pseudomonas aeruginosa (P. aeruginosa) pneumonia is much more common and far more lethal in the elderly. The immunologic mechanisms responsible for this age-dependent response are poorly understood but are likely associated with aberrant immune function in the aged. The intrinsic defects in innate immune cells that have been identified in the older subjects and the elevated basal inflammatory state seen in these individuals are thought to play a role in the inability of neutrophils to rapidly migrate to sites of infection and efficiently perform their phagocytic and antimicrobial tasks, clearing and killing pathogens. In this review chapter, we will discuss the literature examining the effects of P. aeruginosa infection and neutrophil function as it pertains to the vulnerable aging population with the hope that the research community will see the growing need to develop potential targeted therapeutic options for this at-risk and expanding patient population.

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Abbreviations

CXCL1:

Chemokine (CXC motif) ligand 1

fMLP:

N-formylmethionyl-leucyl-phenylalanine

G-CSF:

Granulocyte colony-stimulating factor

GM-CSF:

Granulocyte macrophage colony-stimulating factor

HSV:

Human syncytial virus

ICAM-1:

Intercellular adhesion molecule -1

iNOS:

Inducible nitrous oxide synthase

LPS:

Lipopolysaccharide

PA:

Pseudomonas aeruginosa

PAFr:

Platelet-activating factor receptor

PI3K:

Phosphoinositide-3-kinase

PMA:

Phorbol-12-myristate-13-acetate

ROS:

Reactive oxygen species

SHP-1:

Signal tyrosine phosphotase-1

TLR:

Toll-like receptor

TREM-1:

Triggering receptor expressed on myeloid cell-1

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Acknowledgments

This work was supported in part by NIH R01 AG018859 (EJK) and F30AA022856 (MMC). The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH.

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Authors and Affiliations

  1. Department of Surgery, Division of GI, Endocrine and Tumor Surgery, University of Colorado Denver, Aurora, CO, USA

    Devin M. Boe & Elizabeth J. Kovacs

  2. Graduate Program in Immunology, University of Colorado Denver, Aurora, CO, USA

    Devin M. Boe & Elizabeth J. Kovacs

  3. Mucosal Inflammation Program, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA

    Devin M. Boe & Elizabeth J. Kovacs

  4. Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA

    Michael M. Chen

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  1. Devin M. Boe
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  2. Michael M. Chen
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Correspondence to Devin M. Boe .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Boe, D.M., Chen, M.M., Kovacs, E.J. (2018). Age-Related Dysfunction in the Innate Immune Response to Lung Infections. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_91-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_91-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-64597-1

  • Online ISBN: 978-3-319-64597-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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