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Immunology of Osteoporosis

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Handbook of Immunosenescence

Abstract

In healthy bone, resorption and formation are balanced. Bone metabolism involves different cells and is influenced by many regulatory factors: age, genetics, mechanical stimulus, hormones, endocrine diseases, and medication. Disturbances in bone metabolism may lead to osteoporosis, a frequent disease in postmenopausal women, elderly subjects, patients suffering from inflammatory diseases, as well as patients who need glucocorticoids or immunosuppressive medication. Osteoclasts and immune cells share the same progenitors, the same microenvironment, and a number of regulatory molecules as well. The tight connection between the bone and immune cells explains the cross talk between these systems. In this chapter, the negative effects of the decline of ovarian function, senescence-associated inflammaging, pro-inflammatory cytokines expressed by immune cells, and immunosuppressive therapy on bone metabolism are described, and especially immunological aspects are highlighted. Studies further evaluating the cross talk between the bone and immune cells may lead to new, even more effective therapeutic strategies for the prevention and treatment of primary and secondary osteoporosis.

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Kerschan-Schindl, K., Valenzuela, E.N., Pietschmann, P. (2018). Immunology of Osteoporosis. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_153-1

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