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Benign and Atypical Apocrine Lesions

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  • First Online:
Breast Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Apocrine adenosis; Apocrine atypia; Apocrine change; Apocrine metaplasia; Atypical apocrine adenosis

Definition

Apocrine metaplasia: This is a change of native breast ductal epithelial cells into cells showing eosinophilic granular cytoplasm, a large open nucleus with a single nucleolus, and decapitation secretion. Apocrine metaplasia can be subtyped into simple, papillary, and complex depending on architectural complexity. Apocrine metaplasia can coexist with columnar cell change (Columnar Cell Lesions), sometimes even involving the same duct spaces.

Apocrine adenosis: This is apocrine change in sclerosing adenosis (Sclerosing Adenosis). Some authors use a different definition, as a haphazard proliferation of bland glands with apocrine differentiation and use this term as synonymous with adenomyoepithelial adenosis.

Atypical apocrine change within sclerosing adenosis (atypical apocrine adenosis): Generally seen in postmenopausal women, these cases are defined as having a 3×...

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References and Further Reading

  • Calhoun, B. C., & Booth, C. N. (2014). Atypical apocrine adenosis diagnosed on breast core biopsy: Implications for management. Human Pathology, 45, 2130–2135.

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  • Celis, J. E., Moreira, J. M. A., Gromova, I., Cabezón, T., Gromov, P., Shen, T., Timmermans, V., & Rank, F. (2007). Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia. Molecular Oncology, 1, 97–119.

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  • Collins, L. C., Cole, K. S., Marotti, J. D., Hu, R., Schnitt, S. J., & Tamimi, R. M. (2011). Androgen receptor expression in breast cancer in relation to molecular phenotype: Results from the Nurses’ Health Study. Modern Pathology, 14, 924–931.

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  • Fuehrer, N., Hartmann, L., Degnim, A., Allers, T., Vierkant, R., Frost, M., & Visscher, D. (2012). Atypical apocrine adenosis of the breast: Long-term follow-up in 37 patients. Archives of Pathology and Laboratory Medicine, 136, 179–182.

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  • Gromov, P., Espinoza, J. A., & Gromova, I. (2015). Molecular and diagnostic features of apocrine breast lesions. Expert Review of Molecular Diagnostics, 15, 1011–1022.

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  • Selim, A. G. A., Ryan, A., El-Ayat, G., & Wells, C. A. (2002). Loss of heterozygosity and allelic imbalance in apocrine metaplasia of the breast: Microdissection microsatellite analysis. The Journal of Pathology, 196, 287–291.

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Author information

Authors and Affiliations

  1. University College London Hospital, London, UK

    Reena Khiroya & Clive Wells

Authors
  1. Reena Khiroya
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  2. Clive Wells
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Corresponding author

Correspondence to Reena Khiroya .

Editor information

Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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Khiroya, R., Wells, C. (2020). Benign and Atypical Apocrine Lesions. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4739

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  • DOI: https://doi.org/10.1007/978-3-319-62539-3_4739

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62538-6

  • Online ISBN: 978-3-319-62539-3

  • eBook Packages: MedicineReference Module Medicine

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