Generic Name
Trimipramine.
Brand Name
Surmontil.
Class
Tricyclic antidepressant.
Proposed Mechanism(s) of Action
Serotonin and norepinephrine reuptake inhibitor.
Indication
Depression, endogenous depression.
Off-Label Use
Anxiety, insomnia, neuropathic pain, chronic pain, and depression (treatment-resistant).
Side Effects
Serious
QTc prolongation, seizures, lowered seizure threshold, liver failure, hyperthermia, increased intraocular pressure, orthostatic hypertension, arrhythmias, tachycardia, and sudden death.
Common
Blurred vision, constipation, fatigue, sedation, headache, diarrhea, heartburn, appetite disturbance, weight gain, anxiety, sexual dysfunction, sweating, and rash.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential Psychopharmacology: The Prescriber’s Guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html.
Drug Molecule Images. http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software. www.epocrates.com.
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList.
Pill Identification. http://www.drugs.com/pill_identification.html.
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Courtney, J.C., Akins, C., Gonzalez, E.A. (2018). Trimipramine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1720
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1720
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