Generic Name
Trazodone, Trazodone Hydrochloride (Extended Release)
Brand Name
Desyrel, Oleptro
Class
Antidepressant and hypnotic
Proposed Mechanism(s) of Action
Blocks serotonin 2A receptors and the serotonin reuptake mechanism. The former mechanism of action theoretically underlies its hypnotic effects.
Indication
Depression.
Off-Label Use
Insomnia and anxiety.
Side Effects
Serious
(All rare) priapism, seizures, induction of mania, and suicidal ideation (although short-term studies do not support this warning compared to placebo after age 24).
Common
Nausea, vomiting, dry mouth, dizziness, constipation, edema, hypotension, tremor, syncope, rare bradycardia, and rash.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Centerwatch. https://www.centerwatch.com/drug-information/fda-approved-drugs/drug/1015/edluar-zolpidem-tartrate.
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html.
Drug Molecule Images. http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software. www.epocrates.com.
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi%20bin/ddiD4?ver=4&task=getDrugList.
Pill Identification. http://www.drugs.com/pill_identification.html.
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Courtney, J.C., Gonzalez, E.A. (2018). Trazodone. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1717
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1717
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