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Mirtazapine

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Generic Name

Mirtazapine

Brand Name

Remeron and Remeron Soltab

Class

Antidepressant

Proposed Mechanism(s) of Action

Alpha 2 antagonist (presynaptic autoreceptor antagonist), 5HT2a/c and 5HT3 antagonist, and antihistamine

Indication

Major depressive disorder

Off-Label Use

Panic disorder, generalized anxiety disorder, PTSD, and sedation

Side Effects

Somnolence, weight gain, xerostomia, increased appetite, and constipation

Serious

Seizures (rare), induction of mania (rare), and agranulocytosis (rare) activation of suicidal ideation (controversial)

Common

Dry mouth, constipation, increased appetite, weight gain, sedation, dizziness, abnormal dreams, and hypotension

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References and Readings

  • Physicians’ desk reference (62nd ed.) (2007). Montvale: Thomson PDR.

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  • Physicians’ desk reference (71st ed.) (2017). Montvale, NJ: Thomson PDR.

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Correspondence to Efrain Antonio Gonzalez .

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© 2018 Springer International Publishing AG, part of Springer Nature

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Courtney, J.C., Gonzalez, E.A. (2018). Mirtazapine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1677

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