Memantine

Generic Name

Memantine

Brand Name

Namenda

Class

N-methyl-d-aspartate (NMDA) receptor antagonist

Proposed Mechanism(s) of Action

This agent appears to be a mild to moderate NMDA receptor antagonism, binding more frequently to the NMDA receptor cation channels. Via a similar action, it appears to modulate excessive glutamate release in both Alzheimer’s disease and, theoretically, post-CNS trauma.

Indication

Moderate to severe Alzheimer’s dementia

Off-Label Use

Mild to moderate Alzheimer’s dementia, memory disorders in other conditions, mild cognitive impairment, and chronic pain

Side Effects

Dizziness, confusion, headache, constipation, cough, hypertension, and somnolence

Serious

Seizures (rare)

Common

Dizziness, headache, and constipation