Generic Name
Amoxapine
Brand Name
Ascendin
Class
Tetracyclic antidepressant
Proposed Mechanism(s) of Action
Amoxapine inhibits reuptake of norepinephrine and noradrenaline. It is also known to antagonize serotonin 2A receptors, thus increasing presynaptic release of amines. Mild dopamine 2 blockade.
Indication
Depression, reactive depressive disorder, psychotic depression, and depression accompanied by anxiety or agitation.
Off-Label Use
Depressive phase of a bipolar disorder, anxiety, insomnia, neuropathic pain, and treatment-resistant depression.
Side Effects
Serious
Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, intraocular pressure, mania, and potential for activation of suicidal ideation.
Common
Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue, weakness, dizziness, anxiety, sexual dysfunction, sweating, rash, and...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Readings
Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html.
Drug Molecule Images. http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software. www.epocrates.com.
Free Drug Online and PDA Software. www.medscape.com.
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com: 8080/cgi bin/ddiD4?ver=4&task=getDrugList.
Pill Identification. http://www.drugs.com/pill_identification.html.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this entry
Cite this entry
Gonzalez, E.A. (2018). Amoxapine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1626
Download citation
DOI: https://doi.org/10.1007/978-3-319-57111-9_1626
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
eBook Packages: Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences