Clomipramine

Generic Name

Clomipramine.

Brand Name

Anafranil.

Class

Tricyclic antidepressant.

Proposed Mechanism(s) of Action

Boosts neurotransmitters serotonin and norepinephrine/noradrelaline; blocks serotonin transporter; apparently desensitizes both serotonin 1A receptors and beta adrenergic receptors.

Indication

Obsessive-compulsive disorder, depression, cataplexy syndrome, premature ejaculation.

Off-Label Use

Anxiety, insomnia, chronic pain.

Side Effects

Serious

Paralytic ileus, hyperthermia, lowered seizure threshold and rare seizures, orthostatic hypotension, sudden death, arrhythmias, tachycardia, QTc prolongation, increased intraocular pressure, hepatic failure, extrapyramidal symptoms, mania, and suicidal ideation.

Common

Blurred vision, constipation, increased appetite, urinary retention, dry mouth, nausea, diarrhea, heartburn, strange taste in mouth, weight gain, fatigue, weakness, dizziness, headache, anxiety, nervousness, restlessness, sedation, sexual dysfunction, sweating.