Encyclopedia of Clinical Neuropsychology

Living Edition
| Editors: Jeffrey Kreutzer, John DeLuca, Bruce Caplan


  • Cristy Akins
  • Efrain Antonio Gonzalez
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-3-319-56782-2_1633-3

Generic Name

Bupropion, Bupropion hydrobromide

Brand Name

Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Buproban, Budeprion SR, and Forfivo XL


Antidepressants, smoking cessation aids, and dopamine reuptake inhibitors

Proposed Mechanism(s) of Action

Increases norepinephrine/noradrenaline and dopamine, blocks norepinephrine reuptake pump, may increase dopamine neurotransmission in the frontal cortex, and blocks dopamine reuptake pump.


Major depressive disorder, seasonal affective disorder, and smoking cessation.

Off-Label Use

Bipolar disorder, ADHD, and neuropathic pain.

Side Effects


Seizures, hypomania, induction of mania, and activation of suicidal ideation (controversial).


Dry mouth, constipation, nausea, weight loss, insomnia, dizziness, headache, agitation, tremor, abdominal pain, tinnitus, tremor, palpitation, anorexia, urinary frequency, and sweating.

References and Reading

  1. Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software: www.epocrates.com.
  2. Free Drug Online and PDA Software: www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mercy Family CenterMetarieUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA