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Agomelatine and Depressions

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NeuroPsychopharmacotherapy
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Abstract

Agomelatine is an antidepressant drug acting as melatonergic MT1- and MT2-receptor agonist and selective serotonergic 5-HT2C-antagonist. The efficacy in treatment of major depressive disorder was established in randomized, double-blind, placebo controlled studies and a maintenance study in adult in- and outpatients. Positive effects on sleep parameters have been reported. Side effects are rare; weight gain, sexual dysfunction, or discontinuation syndromes are missing; increase of hepatic transaminases values must be monitored, however; and agomelatine is contraindicated in patients with liver impairment.

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Correspondence to Gerd Laux .

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Laux, G. (2021). Agomelatine and Depressions. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_31-1

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  • DOI: https://doi.org/10.1007/978-3-319-56015-1_31-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56015-1

  • Online ISBN: 978-3-319-56015-1

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