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Biomimetic Models of the Microcirculation for Scientific Discovery and Therapeutic Testing

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Vascularization for Tissue Engineering and Regenerative Medicine

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

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Abstract

Tissue engineering and regenerative medicine therapies require understanding how molecules and cells coordinate together to influence system level behavior. A key obstacle to advancing our understanding of physiological systems is the inability to probe the specific component-level effects when biological experiments fall short of providing the necessary spatial and temporal resolution over the time course of a response. Hence, a critical question emerges: How can we gain new views not possible with in vivo experiments? The objective of this chapter will be to highlight the impact of biomimetic models, including in vitro, ex vivo, and computational approaches for advancing our understanding of the cellular dynamics involved in microvascular remodeling, which is needed for engineering thick tissues and a common denominator for many pathologies. This overview emphasizes the multiscale cellular complexity of microvascular growth and provides examples of integrative models that offer novel perspectives.

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Authors and Affiliations

  1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA

    Robert M. Dolan, Jessica Motherwell, Nicholas Hodges, Ariana D. Suarez-Martinez, Peter McFetridge & Walter L. Murfee

  2. College of Engineering, University of Georgia, Athens, GA, USA

    Cheryl Gomillion

  3. Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA

    Malisa Sarntinoranont

  4. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA

    Shayn M. Peirce

  5. Department of Chemical and Biomolecular Engineering, Lafayette College, Easton, PA, USA

    Chris Anderson

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  1. Robert M. Dolan
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  2. Jessica Motherwell
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  3. Nicholas Hodges
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  4. Ariana D. Suarez-Martinez
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  6. Cheryl Gomillion
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  7. Malisa Sarntinoranont
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  8. Shayn M. Peirce
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  9. Chris Anderson
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  10. Walter L. Murfee
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Correspondence to Walter L. Murfee .

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Editors and Affiliations

  1. Austrian Cluster for Tissue Engineering, Vienna, Austria

    Wolfgang Holnthoner

  2. Department of Biomedicine, University Hospital Basel, Basel, Switzerland

    Andrea Banfi

  3. Institute for Pathology, Johannes Gutenberg University, Mainz, Germany

    James Kirkpatrick

  4. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Wien, Austria

    Heinz Redl

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Dolan, R.M. et al. (2021). Biomimetic Models of the Microcirculation for Scientific Discovery and Therapeutic Testing. In: Holnthoner, W., Banfi, A., Kirkpatrick, J., Redl, H. (eds) Vascularization for Tissue Engineering and Regenerative Medicine. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-54586-8_22

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