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Use of Resampling Procedures to Investigate Issues of Model Building and Its Stability

  • Willi SauerbreiEmail author
  • Anne-Laure Boulesteix
Living reference work entry

Abstract

This chapter deals with issues in model building and the use of resampling procedures to assess model stability. Concentrating on the nonparametric bootstrap and taking material from five papers published between 1992 and 2015, procedures for variable selection, selection of the functional form for continuous variables, and treatment-covariate interactions are discussed. The methods are illustrated by using publicly available data from three randomized trials. General issues related to the selection of regression models as well as bootstrap procedures used as a pragmatic approach to gain further knowledge from clinical data are briefly outlined.

Keywords

Bootstrap Continuous variables Variable selection Treatment interactions Functional form Stability investigations 

Notes

Acknowledgment

A special thanks to Harald Binder, Anika Buchholz, Patrick Royston, and Martin Schumacher, the co-authors of the papers which were used as cornerstones for this article. We also thank Georg Heinze and Christine Wallisch for comments on an earlier version, Alethea Charlton and Jenny Lee for linguistic improvements, and Tim Haeussler, Martin Haslberger, and Andreas Ott for administrative assistance. Finally, we thank the Deutsche Forschungsgemeinschaft who supported parts of the work with grants BO3139/4–3 to ALB and SA580/8–3 to WS and with grants to projects leading to some of the earlier papers.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Medical Biometry and StatisticsFaculty of Medicine and Medical Center - University of FreiburgFreiburgGermany
  2. 2.Institute for Medical Information Processing, Biometry, and EpidemiologyLMU MunichMunichGermany

Section editors and affiliations

  • Stephen George
    • 1
  1. 1.Dept. of Biostatistics and Bioinformatics,Basic Science DivisonDuke University, School of MedicineDurhamUSA

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