Extrusion Pumps for Hydrocarbons: An Efficient Evolutionary Strategy to Confer Resistance to Hydrocarbons
Efflux pumps of the RND family are primarily involved in the extrusion of hydrocarbons. These pumps, specific to gram-negative bacteria, are composed of three components. Two components are transmembrane proteins located in the inner and outer membrane whereas the third one spans the periplasm connecting the other two subunits. The large part of information available on RND pumps is related to their capacity to extrude antibiotics. Structural data indicate that substrate binding may occur preferentially in the periplasm at the inner membrane protein.
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