Synthetic Biology for Biofuels in Saccharomyces cerevisiae

  • Wei Suong Teo
  • Yu Chyuan Heng
  • Binbin Chen
  • Hui Ling Lee
  • Niying Chua
  • Matthew Wook Chang
Reference work entry
Part of the Handbook of Hydrocarbon and Lipid Microbiology book series (HHLM)


The yeast Saccharomyces cerevisiae has crucial features to facilitate successful genetic engineering and industrial scale fermentations for producing drop-in biofuels. Short-chain alcohols, fatty acid derivatives, and isoprenoids are potential drop-in biofuels where their biosynthesis can help mitigate climate change while ensuring sustainability of energy supply. Here, we review the drop-in biofuel molecules that have been produced in engineered S. cerevisiae. Efforts to diversify and optimize biofuel production using synthetic biology and metabolic engineering approaches are discussed. Much improvement will be required to achieve commercial viability.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Wei Suong Teo
    • 1
    • 3
  • Yu Chyuan Heng
    • 1
    • 2
  • Binbin Chen
    • 1
    • 3
  • Hui Ling Lee
    • 1
    • 3
  • Niying Chua
    • 1
    • 3
  • Matthew Wook Chang
    • 1
    • 3
  1. 1.Department of Biochemistry, Yong Loo Lin School of Medicine, and NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences InstituteNational University of SingaporeSingaporeSingapore
  2. 2.Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)SingaporeSingapore
  3. 3.School of Life Sciences and Chemical TechnologyNgee Ann PolytechnicSingaporeSingapore

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