Production of Fatty Acids and Derivatives by Metabolic Engineering of Bacteria

  • Christopher R. Mehrer
  • Nestor J. Hernández Lozada
  • Rung-Yi Lai
  • Brian F. Pfleger
Reference work entry
Part of the Handbook of Hydrocarbon and Lipid Microbiology book series (HHLM)


Metabolic engineering provides a powerful set of tools to engineer organisms such as bacteria, fungi, and plants to produce chemicals of interest. Fatty acid metabolism enables the sustainable production of many oleochemicals used as fuels, materials, and consumer products. In this chapter, we describe the biochemical pathways and metabolic engineering strategies that have been employed in bacteria to produce fatty acids and their related oleochemical products, such as alkanes, olefins, ketones, esters, alcohols, and polyesters. While microbial oleochemical production is promising, significant work remains to address the metabolic, physiological, and process engineering barriers that obstruct economic commercial deployment.


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© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Christopher R. Mehrer
    • 1
  • Nestor J. Hernández Lozada
    • 1
  • Rung-Yi Lai
    • 1
  • Brian F. Pfleger
    • 1
  1. 1.Department of Chemical and Biological EngineeringUniversity of Wisconsin-MadisonMadisonUSA

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