Chemical Production: Biohalogenation
Natural and synthetic organohalogens are used in a variety of applications, and with an increasing emphasis on sustainable methods of production, enzymes that can form carbon-halogen bonds are an attractive alternative to classical synthetic approaches. Since the discovery of FADH2-dependent halogenases 20 years ago, there has been a dramatic increase in our understanding of biological halogenation reactions, with several distinct classes of halogenating enzymes identified. In this chapter, an overview of the various halogenases is given and examples of how these can be applied to the production of biotechnologically important compounds.
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