Skip to main content
SpringerLink
Log in

Biomedical Applications of Chitosan

  • Living reference work entry
  • First Online:
Book cover Handbook of Ecomaterials

  • 830 Accesses

Abstract

In the past few decades, extensive researches are being undertaken to develop innovative drug delivery systems and improve scaffolds for regenerative/alternative substances that are currently one of the most rapidly growing fields of modern science. Chitosan (CH) is a copolymer, composed of glucosamine and N-acetylglucosamine, and considered as a polycationic, biocompatible, and biodegradable polymer. It is one of the most explored and studied polymers. It bears several reactive functional groups, which make it capable of possessing strong biological properties with less toxicity, biodegradability, and environmental compatibility. Due to its low solubility, it has limitation for biomedical purposes. Chemical modification into composites or hydrogels provides versatile biomaterials because of their nontoxicity, low allergenicity, biocompatibility, and biodegradability. This chapter discusses the several biomedical applications of CH.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  1. Dasha M, Chiellini F, Ottenbriteb RM, Chiellini E (2011) Chitosan-A versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci 36:981–1014

    Article  Google Scholar 

  2. Wan Ngah WS, Ariff NFM, Hashim A, Hanafiah MAKM (2010) Malachite green adsorption onto chitosan coated bentonite beads: isotherms, kinetics and mechanism. Clean: Soil, Air, Water 38:394–400

    Google Scholar 

  3. Zhang X, Yang X, Ji J, Liu A, Zhai G (2016) Tumor targeting strategies for chitosan-based nanoparticles. Colloids Surf B Biointerfaces 148:460–473

    Article  Google Scholar 

  4. Davoodbasha M, Kim S-C, Lee S-Y, Kim J-W (2016) The facile synthesis of chitosan-based silver nano-biocomposites via a solution plasma process and their potential antimicrobial efficacy. Arch Biochem Biophys 605:49–58

    Article  Google Scholar 

  5. Suh JK, Matthew HW (2000) Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomater 21(24):2589–2598

    Article  Google Scholar 

  6. Marques J, Valle-Delgado JJ, Urbán P, Baró E, Prohens R, Mayor A et al (2017) Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery. Nanomedicine Nanotechnol Biol Med 13:515–525

    Article  Google Scholar 

  7. Dutta PK, Dutta J, Tripathi VS (2004) Chitin and chitosan: chemistry, properties and applications. J Sci Ind Res 63:20–31

    Google Scholar 

  8. Vinsova J, Vavrikova E (2011) Chitosan derivatives with antimicrobial, antitumour and antioxidant activities-a review. Curr Pharm Des 17(32):3596–3607

    Article  Google Scholar 

  9. de la Fuente M, Ravina M, Paolicelli P, Sanchez A, Seijo B, Alonso MJ (2010) Chitosan-based nanostructures: a delivery platform for ocular therapeutics. Adv Drug Deliv Rev 62:100–117

    Article  Google Scholar 

  10. Saber A, Strand SP, Ulfendahl M (2010) Use of the biodegradable polymer chitosan as a vehicle for applying drugs to the inner ear. Eur J Pharm Sci 39:110–115

    Article  Google Scholar 

  11. Park JH, Saravanakumar G, Kim K, Kwon IC (2010) Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev 62:28–41

    Article  Google Scholar 

  12. Hu Y, Jiang X, Ding Y, Ge H, Yuan Y, Yang C (2002) Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles. Biomater 23:3193–3201

    Article  Google Scholar 

  13. Hejazi R, Amiji M (2003) Stomach-specific anti-H pylori therapy. II. Gastric residence studies of tetracycline-loaded chitosan microspheres in gerbils. Pharm Dev Technol 8:253–262

    Article  Google Scholar 

  14. Nagamoto T, Hattori Y, Takayama K, Maitani Y (2004) Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery. Pharm Res 21:671–674

    Article  Google Scholar 

  15. Amidi M, Mastrobattista E, Jiskoot W, Hennink WE (2010) Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev 62:59–82

    Article  Google Scholar 

  16. Read RC, Naylor SC, Potter CW, Bond J, Jabbal-Gill I, Fisher A, Illum L, Jennings R (2005) Effective nasal influenza vaccine delivery using chitosan. Vaccine 23:4367–4374

    Article  Google Scholar 

  17. Nishimura K, Nishimura S, Nishi N, Numata F, Tone Y, Tokura S, Azuma I (1985) Adjuvant activity of chitin derivatives in mice and guineapigs. Vaccine 3:379–384

    Article  Google Scholar 

  18. Ahn JS, Choi HK, Cho CS (2001) A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of chitosan. Biomater 22:923–928

    Article  Google Scholar 

  19. Aggarwal A, Kaur S, Tiwary AK, Gupta S (2001) Chitosan microspheres prepared by an aqueous process: release of indomethacin. J Microencapsul 18:819–823

    Article  Google Scholar 

  20. Huang YC, Yeh MK, Cheng SN, Chiang CH (2003) The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method. J Microencapsul 20:459–472

    Article  Google Scholar 

  21. Mattioli-Belmonte M, Gigante A, Muzzarelli RA, Politano R, De Benedittis A, Specchia N, Buffa A, Biagini G, Greco F (1999) N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage. Med Biol Eng Comput 37:130–134

    Google Scholar 

  22. Seol YJ, Lee JY, Park YJ, Lee YM, Young K, Rhyu IC, Lee SJ, Han SB, Chung CP (2004) Chitosan sponges as tissue engineering scaffolds for bone formation. Biotechnol Lett 26:1037–1041

    Article  Google Scholar 

  23. Seeherman H, Li R, Wozney J (2003) A review of preclinical program development for evaluating injectable carriers for osteogenic factors. J Bone Joint Surg Am 85A(Suppl 3):96–108

    Article  Google Scholar 

  24. De Silva RT, Mantilaka MM, Ratnayake SP, Amaratunga GA, de Silva KN (2017) Nano-MgO reinforced chitosan nanocomposites for high performance packaging applications with improved mechanical, thermal and barrier properties. Carbohydr Polym 157:739–747

    Article  Google Scholar 

  25. Yang L, Wang Q, Peng L, Yue H, Zhang Z (2015) Vascularization of repaired limb bone defects using chitosan-β-tricalcium phosphate composite as a tissue engineering bone scaffold. Mol Med Rep 12:2343–2347

    Article  Google Scholar 

  26. Dai T, Tanaka M, Huang YY, Hamblin MR (2011) Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Exp Rev Anti-infect Therapy 9(7):857–879

    Article  Google Scholar 

  27. Muzzarelli RAA, Muzzarelli C, Tarsi R, Miliani M, Gabbanelli F, Cartolari M (2001) Fungistatic activity of modified chitosans against Saprolegnia parasitica. Biomacromol 2(1):165–169

    Article  Google Scholar 

  28. Liu XF, Guan YL, Yang DZ, Li Z, Yao KD (2001) Antibacterial action of chitosan and carboxymethylated chitosan. J Appl Polym Sci 79(7):1324–1335

    Article  Google Scholar 

  29. Cheung RC, Ng TB, Wong JH, Chan WY (2015) Chitosan: an update on potential biomedical and pharmaceutical applications. Mar Drugs 13(8):5156–5186

    Article  Google Scholar 

  30. Makadia HK, Siegel SJ (2011) Poly Lactic-co-Glycolic Acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 3:1377–1397

    Article  Google Scholar 

  31. Emami J, Rezazadeh M, Hasanzadeh F, Sadeghi H, Mostafavi A, Minaiyan M, Rostami M, Davies N (2015) Development and in vitro/in vivo evaluation of a novel targeted polymeric micelle for delivery of paclitaxel. Int J Biol Macromol 80:29–40

    Article  Google Scholar 

  32. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM et al (2015) MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature 518:107–110

    Article  Google Scholar 

  33. Bui VK, Park D, Lee YC (2017) Chitosan combined with ZnO, TiO2 and Ag nanoparticles for antimicrobial wound healing applications: a mini review of the research trends. Polymers. https://doi.org/10.3390/polym9010021

  34. Ishihara M, Nakanishi K, Ono K, Sato M, Kikuchi M, Saito Y, Yura H, Matsui T, Hattori H, UenoyamaM KA (2002) Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process. Biomater 23:833–840

    Article  Google Scholar 

  35. Wang L, Khor E, Wee A, Lim LY (2002) Chitosan-alginate PEC membrane as a wound dressing: assessment of incisional wound healing. J Biomed Mater Res 63:610–618

    Article  Google Scholar 

  36. Sathiyaseelan A, Shajahan A, Kalaichelvan PT, Kaviyarasan V (2017) Fungal chitosan based nanocomposites sponges – an alternative medicine for wound dressing. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2017.03.188

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, YMD College, Maharshi Dayanand University, Nuh, Haryana, 122107, India

    Mohd Yusuf

Authors
  1. Mohd Yusuf
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohd Yusuf .

Editor information

Editors and Affiliations

  1. Instituto de Ingeniería Civil, Universidad Autónoma de Nuevo León Instituto de Ingeniería Civil, San Nicolás de los Garza, Nuevo León, Mexico

    Leticia Myriam Torres Martínez

  2. Universidad Autónoma de Nuevo León , Monterrey, Mexico

    Oxana Vasilievna Kharissova

  3. Universidad Autónoma de Nuevo León , Monterrey, Mexico

    Boris Ildusovich Kharisov

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this entry

Cite this entry

Yusuf, M. (2017). Biomedical Applications of Chitosan. In: Martínez, L., Kharissova, O., Kharisov, B. (eds) Handbook of Ecomaterials. Springer, Cham. https://doi.org/10.1007/978-3-319-48281-1_57-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-48281-1_57-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-48281-1

  • Online ISBN: 978-3-319-48281-1

  • eBook Packages: Springer Reference EngineeringReference Module Computer Science and Engineering

Publish with us

Policies and ethics

Search

Navigation