Follicle-stimulating hormone (FSH) is a glycoprotein hormone that acts primarily at the gonads to regulate multiple aspects of reproductive physiology in both males and females, including gametogenesis, follicle maturation, and steroidogenesis.
FSH, and the closely related luteinizing hormone (LH) and chorionic gonadotropin (CG) form a class of hormones called the gonadotropins that regulate the physiology and function of the gonad. FSH and LH are produced and secreted by gonadotrope cells in the anterior pituitary gland and all gonadotropins are composed of two distinct subunits, an alpha subunit that is common to FSH, LH, CG, and thyroid-stimulating hormone, and a beta subunit that differs among these four hormones and confers specificity of function to each. The alpha and beta subunits are bonded noncovalently and each contain numerous oligosaccharides attached to the amino acid backbones. Different patterns and...
- Ball, G. F., & Bentley, G. E. (2000). Neuroendocrine mechanisms mediating the photoperiodic and social regulation of seasonal reproduction in birds. In K. Wallen & J. E. Schneider (Eds.), Reproduction in context: Social and environmental influences on reproduction (pp. 129–158). Cambridge, MA: MIT Press.Google Scholar
- Hall, J. E. (2016). Neuroendocrine control of the menstrual cycle. In Yen & Jaffe’s reproductive endocrinology: Physiology, pathophysiology, and clinical management (7th ed., pp. 141–156.e4). Philadelphia: Elsevier.Google Scholar
- Liu, P. Y., & Veldhuis, J. D. (2016). The hypothalamo-pituitary unit, testis, and male accessory organs. In Yen & Jaffe’s reproductive endocrinology: Physiology, pathophysiology, and clinical management (7th ed., pp. 272–286.e8). Philadelphia: Elsevier.Google Scholar
- Mullen, M. P., Cooke, D. J., & Crow, M. A. (2013). Structural and functional roles of FSH and LH as glycoproteins regulating reproduction in mammalian species. Gonadotropin (Vizcarra, J. Ed.), InTech. doi: https://doi.org/10.5772/48681.
- Plant, T. M., & Marshall, G. R. (2001). The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocrine Reviews, 22, 764–786.Google Scholar
- Snyder, P. J. (2016). Male reproductive aging. In Yen & Jaffe’s reproductive endocrinology: Physiology, pathophysiology, and clinical management (7th ed., pp. 340–348.e2). Philadelphia: Elsevier.Google Scholar
- Velasquez, E. V. (2006). Pituitary-ovarian axis during lactational amenorrhoea. I. Longitudinal assessment of follicular growth, gonadotrophins, sex steroids and inhibin levels before and after recovery of menstrual cyclicity. Human Reproduction, 21, 909–915.Google Scholar