Encyclopedia of Animal Cognition and Behavior

Living Edition
| Editors: Jennifer Vonk, Todd Shackelford

MicroRNA

  • Akash Mallick
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-47829-6_171-1

Synonyms

Definition

MicroRNAs or miRNAs are small noncoding RNAs, which regulate gene expression at posttranscriptional level through RNA-protein interactions and thus influential for varieties of biological processes.

Introduction

MicroRNAs (miRNAs) are small, functional noncoding RNAs of ~22 nucleotides – which are integral part of gene expression regulation at posttranscriptional level. They are involved in a wide array of biological processes such as cellular growth, proliferation, and differentiation and other fine-tuned developmental processes (Ameres and Zamore 2013). Such small RNAs were first discovered in Caenorhabditis elegans while finding the role of lin-4 in postembryonic cell lineage formation. Interestingly it was found that lin-4 does not code for any protein but represses lin-14 expression for proper lineage progression. Surprisingly, nothing much could be deciphered except the fact that both of them share high degree of sequence complementarity (Lee et al. 1993...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Chemical BiologyCSIR-Indian Institute of Chemical TechnologyHyderabadIndia

Section editors and affiliations

  • Akash Gautam
    • 1
  1. 1.Centre for Neural and Cognitive Sciences, School of Medical SciencesUniversity of HyderabadHyderabadIndia