MicroRNAs or miRNAs are small noncoding RNAs, which regulate gene expression at posttranscriptional level through RNA-protein interactions and thus influential for varieties of biological processes.
MicroRNAs (miRNAs) are small, functional noncoding RNAs of ~22 nucleotides – which are integral part of gene expression regulation at posttranscriptional level. They are involved in a wide array of biological processes such as cellular growth, proliferation, and differentiation and other fine-tuned developmental processes (Ameres and Zamore 2013). Such small RNAs were first discovered in Caenorhabditis elegans while finding the role of lin-4 in postembryonic cell lineage formation. Interestingly it was found that lin-4 does not code for any protein but represses lin-14 expression for proper lineage progression. Surprisingly, nothing much could be deciphered except the fact that both of them share high degree of sequence complementarity (Lee et al. 1993...
- Mathonnet, G., Fabian, M. R., Svitkin, Y. V., Parsyan, A., Huck, L., Murata, T., Biffo, S., Merrick, W. C., Darzynkiewicz, E., Pillai, R. S., Filipowicz, W., Duchaine, T. F., Sonenberg, N. (2007). MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science, 317, 1764–1767.CrossRefPubMedGoogle Scholar
- Wee, L., Flores-Jasso, C. F., Salomon, W. & Zamore, P. D.(2012). Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell, 151, 1055–1067.Google Scholar