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The Endocrine Heart

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Principles of Endocrinology and Hormone Action

Part of the book series: Endocrinology ((ENDOCR))

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Abstract

Mammalian hearts express and secrete natriuretic peptides. Atrial natriuretic peptide (ANP) was the first to be identified in atria of rodents, and today the cardiac peptides consist of also the structurally related B-type natriuretic peptide – or BNP. Both peptide hormones have important hemodynamic properties including regulation of blood pressure and intravascular fluid hemostasis. As biomarkers, biosynthetic precursor fragments have gained a robust function in the assessment of human heart failure, where the markers are used primarily as exclusion markers. As drugs, both ANP and BNP, and derivatives of these peptides, seem promising as therapy in heart failure patients and in hypertension. Moreover, the cardiac peptide hormones may also possess organ-protective effects, where kidney function and cardiac remodeling seem in particular relevant.

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de Bold, A.J., Burnett, J.C., Goetze, J.P. (2018). The Endocrine Heart. In: Belfiore, A., LeRoith, D. (eds) Principles of Endocrinology and Hormone Action. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-44675-2_20

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